| First Author | Matsuyama S | Year | 2004 |
| Journal | Neuroreport | Volume | 15 |
| Issue | 3 | Pages | 417-20 |
| PubMed ID | 15094495 | Mgi Jnum | J:89818 |
| Mgi Id | MGI:3041707 | Doi | 10.1097/00001756-200403010-00007 |
| Citation | Matsuyama S, et al. (2004) Enhanced long-term potentiation in vivo in dentate gyrus of NELL2-deficient mice. Neuroreport 15(3):417-20 |
| abstractText | NELL2 is a neuron-specific thrombospondin-1-like extracellular protein containing six epidermal growth factor-like domains and is highly expressed in the hippocampus. We have previously shown that NELL2 promotes survival of neurons through mitogen-activated protein kinases. To clarify the function of NELL2 in vivo, we have generated a novel strain of mice with a targeted mutation in the NELL2 gene and assessed long-term potentiation (LTP) in vivo in the dentate gyrus of NELL2-deficient mice using extracellular recording techniques. Production of LTP at perforant path-granule cell synapses was significantly larger in NELL2-deficient mice than in wild-type controls. Thus, we propose that NELL2 plays an important role as a novel suppressor in LTP in vivo in the mouse dentate gyrus. |
