| First Author | Kisielow P | Year | 1988 |
| Journal | Nature | Volume | 333 |
| Issue | 6175 | Pages | 742-6 |
| PubMed ID | 3260350 | Mgi Jnum | J:79738 |
| Mgi Id | MGI:2388863 | Doi | 10.1038/333742a0 |
| Citation | Kisielow P, et al. (1988) Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature 333(6175):742-6 |
| abstractText | The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H-Y) antigen in the context of class I H-2Db MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only transgene-expressing cells with a relatively high surface-density of CD8 molecules, including nonmature CD4+ CD8+ thymocytes, and is not caused by anti-idiotype cells. |
