| First Author | Hettmann T | Year | 2003 |
| Journal | Immunol Lett | Volume | 85 |
| Issue | 3 | Pages | 297-300 |
| PubMed ID | 12663146 | Mgi Jnum | J:128814 |
| Mgi Id | MGI:3768046 | Doi | 10.1016/s0165-2478(02)00260-2 |
| Citation | Hettmann T, et al. (2003) A critical role for NF-kappaB transcription factors in the development of CD8+ memory-phenotype T cells. Immunol Lett 85(3):297-300 |
| abstractText | Memory T cells are essential for generating secondary immune responses and so provide long-lived protection from pathogens. The mechanisms that regulate the differentiation and survival of memory T cells are largely unknown. Transgenic mice in which NF-kappaB activity is inhibited by the expression of a dominant-negative form of IkappaB-alpha (mIkappaB-alpha mice) have drastically diminished numbers of CD8(+) memory-phenotype cells. The development of activated mIkappaB-alpha CD8 cells into memory-phenotype CD8 cells was severely impaired after adoptive transfer to lymphopenic hosts. Our findings demonstrate a critical role for NF-kappaB transcription factors in determining the number of memory-phenotype CD8 cells. |
