| First Author | Martinic MM | Year | 2004 |
| Journal | Eur J Immunol | Volume | 34 |
| Issue | 4 | Pages | 1041-9 |
| PubMed ID | 15048714 | Mgi Jnum | J:88857 |
| Mgi Id | MGI:3037359 | Doi | 10.1002/eji.200424920 |
| Citation | Martinic MM, et al. (2004) Role of TCR-restricting MHC density and thymic environment on selection and survival of cells expressing low-affinity T cell receptors. Eur J Immunol 34(4):1041-9 |
| abstractText | H-Y-specific T cell receptor (TCR) transgenic mice express an MHC class I H-2D(b)-restricted TCR specific for a male antigen-derived peptide (H-Y). Selection and survival of cells expressing this low-affinity TCR were analyzed under optimal and sub-optimal conditions. Optimal conditions were provided by a thymic environment with high H-2D(b) density. Sub-optimal conditions were provided by a thymic environment with decreased H-2D(b) density or by an athymic environment with either high or low H-2D(b) density. Whereas negative selection was still guaranteed under sub-optimal conditions, selection and survival efficiency of cells expressing the transgenic TCR were strongly dependent on optimal conditions. These results indicated that both a thymic microenvironment and a high density of TCR-restricting MHC molecules were needed to ensure selection and maintenance of cells expressing TCR with low affinity and hence a more diverse T cell repertoire. |
