| First Author | Matuszyk J | Year | 1998 |
| Journal | Biochem Biophys Res Commun | Volume | 249 |
| Issue | 1 | Pages | 279-82 |
| PubMed ID | 9705872 | Mgi Jnum | J:52630 |
| Mgi Id | MGI:1329907 | Doi | 10.1006/bbrc.1998.9131 |
| Citation | Matuszyk J, et al. (1998) Thymic lymphomas are resistant to Nur77-mediated apoptosis. Biochem Biophys Res Commun 249(1):279-82 |
| abstractText | We reported previously that thymic lymphomas from mice expressing transgenic TCR autoreactive against male (HY) antigen were resistant to anti-CD3 antibody-mediated induction of apoptosis although they were responding to TCR triggering. To test whether thymic lymphomas were specifically resistant to TCR-dependent Ca(++)-mediated induction of apoptosis, we have measured apoptosis of cells treated with Ca(++)-dependent (ionomycin, A23187) and Ca(++)-independent (etoposide, dexamethasone) inducers of apoptosis. Here we show that, unlike thymocytes, all thymic lymphomas were resistant to Ca(++)-dependent but not to Ca(++)-independent induction of apoptosis. These results excluded a general defect of apoptosis in lymphoma cells and suggested a specific inhibition of the calcium-mediated (TCR-dependent) pathway of apoptosis in lymphomas. Interestingly however, nuclear expression of a specific mediator of TCR-dependent apoptosis Nur77 was induced in ionomycin-resistant lymphomas indicating that, unlike normal thymocytes, thymic lymphomas are resistant to Nur77-mediated apoptosis. |
