| Primary Identifier | MGI:3044953 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Kit |
| Transmission | Germline | Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Cre-mediated recombination removed the floxed neo in Kittm3Bsm, leaving a single loxP site in intron 9 and the tyrosine 567 to phenylalanine mutation. Flow cytometry indicated that receptor levels were reduced to 50-60% of normal levels, and Rnase protection assay showed that transcripts are reduced to 50-60% of normal levels, putatively indicating that the remaining lox site and flanking sequences in intron 9 of the mutant affects RNA transcription and/or splicing. |
