| First Author | Koopman P | Year | 1991 |
| Journal | Nature | Volume | 351 |
| Issue | 6322 | Pages | 117-21 |
| PubMed ID | 2030730 | Mgi Jnum | J:20295 |
| Mgi Id | MGI:68395 | Doi | 10.1038/351117a0 |
| Citation | Koopman P, et al. (1991) Male development of chromosomally female mice transgenic for Sry [see comments]. Nature 351(6322):117-21 |
| abstractText | The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos. |
