| First Author | Wu W | Year | 2015 |
| Journal | Biochem Biophys Res Commun | Volume | 461 |
| Issue | 4 | Pages | 681-6 |
| PubMed ID | 25931000 | Mgi Jnum | J:228474 |
| Mgi Id | MGI:5707132 | Doi | 10.1016/j.bbrc.2015.04.092 |
| Citation | Wu W, et al. (2015) Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation. Biochem Biophys Res Commun 461(4):681-6 |
| abstractText | We investigated the contributions of dietary fat and dietary carbohydrate to the development of fatty liver induced by western diet (WD). Compared with WD-fed wild type (WT) mice, livers of WD-fed ChREBP(-/-) mice showed lipid droplets of varying sizes around the hepatic lobules, while hepatic triglyceride and cholesterol contents were only modestly decreased. Inflammation and fibrosis were suppressed in ChREBP(-/-) mice. In addition, compared with WD-fed WT mice, ChREBP(-/-) mice showed decreased beta-oxidation, ketogenesis and FGF21 production, increased intestinal lipid absorption, and decreased VLDL secretion. These findings suggest that dietary fat and carbohydrate contribute differently to the development of fatty liver. |
