| First Author | Paigen B | Year | 1989 |
| Journal | Genetics | Volume | 122 |
| Issue | 1 | Pages | 163-8 |
| PubMed ID | 2499515 | Mgi Jnum | J:9832 |
| Mgi Id | MGI:58289 | Doi | 10.1093/genetics/122.1.163 |
| Citation | Paigen B, et al. (1989) Ath-2, a second gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice. Genetics 122(1):163-8 |
| abstractText | Strain C57BL/6J and A/J differ at two genes determining atherosclerosis susceptibility. The first gene, Ath-1, was described earlier and this report characterizes Ath-2. The alleles at Ath-2 are r for resistance and s for susceptibility to atherosclerosis. The resistant phenotype in female mice is characterized by high plasma high density lipoprotein-cholesterol levels (74 mg/dl +/- SEM 2) and very few lesions/mouse after 14 weeks of consumption of an atherogenic diet (0.1 +/- SEM 0.1 in a predetermined region of the aorta). The susceptible phenotype in female mice is characterized by low levels of high density lipoprotein-cholesterol (35 mg/dl +/- SEM 1) and 1.2 lesions/mouse +/- SEM 0.2 in the same region of the aorta. In Ath-2 heterozygotes, resistance is dominant to susceptibility. Recombinant inbred strains derived from C57BL/6 and A were characterized for Apoa 1, Apoa 2 and susceptibility to atherosclerosis. Ath-1 and Ath-2 interact with each other so that resistant alleles at either locus confer a resistant phenotype to the animal. The map position of Ath-2 is not known, but Ath-2 does not map near genes determining the apolipoproteins for A-I, A-II, or E. |
