| First Author | Agulnik II | Year | 1998 |
| Journal | Mamm Genome | Volume | 9 |
| Issue | 2 | Pages | 107-10 |
| PubMed ID | 9457669 | Mgi Jnum | J:45873 |
| Mgi Id | MGI:1196652 | Doi | 10.1007/s003359900698 |
| Citation | Agulnik II, et al. (1998) Sex-specific modifiers of tail development in mice heterozygous for the brachyury (T) mutation. Mamm Genome 9(2):107-10 |
| abstractText | The brachyury, or T, locus encodes a transcription factor that plays a crucial role in the early development of all animals. In the mouse, animals heterozygous for a null mutation at this locus are born with a characteristic short tail. Expressivity of the short tail phenotype is greatly affected by genetic background. As a genetic entry into the identification of genes that interact with the Brachyury locus, we have performed a QTL analysis for modifiers of this phenotype. Surprisingly, we discovered that the major modifiers uncovered all act in a sex-limited manner. We have identified two QTLs--Brm1 on Chr 9 and Brm2 on Chr 15--that act only in female offspring(N2) from female T/+ parents(F1) and are responsible together for most, or all, of the genetic variance in phenotypic expression observed between C57BL/10 and C3H/HeJ animals. |
