| First Author | Oliveira da Cruz JF | Year | 2020 |
| Journal | Cell Rep | Volume | 32 |
| Issue | 7 | Pages | 108046 |
| PubMed ID | 32814049 | Mgi Jnum | J:301240 |
| Mgi Id | MGI:6489140 | Doi | 10.1016/j.celrep.2020.108046 |
| Citation | Oliveira da Cruz JF, et al. (2020) Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory. Cell Rep 32(7):108046 |
| abstractText | A complex array of inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically affects memory processes is not well understood. We find that a small subclass of type 1 cannabinoid receptor (CB1R)-expressing hippocampal interneurons determines episodic-like memory consolidation by linking dopamine D1 receptor (D1R) signaling to GABAergic transmission. Mice lacking CB1Rs in D1-positive cells (D1-CB1-KO) display impairment in long-term, but not short-term, novel object recognition memory (NOR). Re-expression of CB1Rs in hippocampal D1R-positive cells rescues this NOR deficit. Learning induces an enhancement of in vivo hippocampal long-term potentiation (LTP), which is absent in mutant mice. CB1R-mediated NOR and the associated LTP facilitation involve local control of GABAergic inhibition in a D1-dependent manner. This study reveals that hippocampal CB1R-/D1R-expressing interneurons control NOR memory, identifying a mechanism linking the diversity of hippocampal interneurons to specific behavioral outcomes. |
