| First Author | Talbot F | Year | 2023 |
| Journal | Nat Commun | Volume | 14 |
| Issue | 1 | Pages | 1450 |
| PubMed ID | 36922513 | Mgi Jnum | J:339803 |
| Mgi Id | MGI:7445868 | Doi | 10.1038/s41467-023-36966-3 |
| Citation | Talbot F, et al. (2023) A rare human variant that disrupts GPR10 signalling causes weight gain in mice. Nat Commun 14(1):1450 |
| abstractText | Disruption of brain-expressed G protein-coupled receptor-10 (GPR10) causes obesity in animals. Here, we identify multiple rare variants in GPR10 in people with severe obesity and in normal weight controls. These variants impair ligand binding and G protein-dependent signalling in cells. Transgenic mice harbouring a loss of function GPR10 variant found in an individual with obesity, gain excessive weight due to decreased energy expenditure rather than increased food intake. This evidence supports a role for GPR10 in human energy homeostasis. Therapeutic targeting of GPR10 may represent an effective weight-loss strategy. |
