| First Author | Meibers HE | Year | 2023 |
| Journal | Cell Rep | Volume | 42 |
| Issue | 10 | Pages | 113180 |
| PubMed ID | 37794597 | Mgi Jnum | J:342154 |
| Mgi Id | MGI:7546697 | Doi | 10.1016/j.celrep.2023.113180 |
| Citation | Meibers HE, et al. (2023) Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells. Cell Rep 42(10):113180 |
| abstractText | Cognate interaction between CD4(+) effector memory T (T(EM)) cells and dendritic cells (DCs) induces innate inflammatory cytokine production, resulting in detrimental autoimmune pathology and cytokine storms. While T(EM) cells use tumor necrosis factor (TNF) superfamily ligands to activate DCs, whether T(EM) cells prompt other DC-intrinsic changes that influence the innate inflammatory response has never been investigated. We report the surprising discovery that T(EM) cells trigger double-strand DNA breaks via mitochondrial reactive oxygen species (ROS) production in interacting DCs. Initiation of the DNA damage response in DCs induces activation of a cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS)-independent, non-canonical stimulator of interferon genes (STING)-TNF receptor-associated factor 6 (TRAF6)-nuclear factor kappaB (NF-kappaB) signaling axis. Consequently, STING-deficient DCs display reduced NF-kappaB activation and subsequent defects in transcriptional induction and functional production of interleukin-1beta (IL-1beta) and IL-6 following their interaction with T(EM) cells. The discovery of T(EM) cell-induced innate inflammation through DNA damage and a non-canonical STING-NF-kappaB pathway presents this pathway as a potential target to alleviate T cell-driven inflammation in autoimmunity and cytokine storms. |
