| First Author | Bromley SK | Year | 2005 |
| Journal | Nat Immunol | Volume | 6 |
| Issue | 9 | Pages | 895-901 |
| PubMed ID | 16116469 | Mgi Jnum | J:100486 |
| Mgi Id | MGI:3588620 | Doi | 10.1038/ni1240 |
| Citation | Bromley SK, et al. (2005) Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat Immunol 6(9):895-901 |
| abstractText | T cell circulation between peripheral tissues and the lymphoid compartment is critical for immunosurveillance and host defense. However, the factors that determine whether T cells remain in peripheral tissue or return to the circulation are undefined. Here we demonstrate that the chemokine receptor CCR7 is a critical signal that determines T cell exit from peripheral tissue. Both CCR7(-) and CCR7(+) effector T cells entered mouse asthmatic lung and while CCR7(-) T cells accumulated, CCR7(+) T cells continued to migrate into afferent lymph. Delivery of both CCR7(+) and CCR7(-) T cells directly into the airways showed that only CCR7(+) T cells exited the lung and entered draining lymph nodes. Our study establishes a molecular basis for T cell exit from peripheral tissues. |
