| First Author | Chen HH | Year | 2015 |
| Journal | PLoS One | Volume | 10 |
| Issue | 11 | Pages | e0142881 |
| PubMed ID | 26587591 | Mgi Jnum | J:244572 |
| Mgi Id | MGI:5913351 | Doi | 10.1371/journal.pone.0142881 |
| Citation | Chen HH, et al. (2015) Eosinophils from Murine Lamina Propria Induce Differentiation of Naive T Cells into Regulatory T Cells via TGF-beta1 and Retinoic Acid. PLoS One 10(11):e0142881 |
| abstractText | Treg cells play a crucial role in immune tolerance, but mechanisms that induce Treg cells are poorly understood. We here have described eosinophils in lamina propria (LP) that displayed high aldehyde dehydrogenase (ALDH) activity, a rate-limiting step during all-trans retinoic acid (ATRA) synthesis, and expressed TGF-beta1 mRNA and high levels of ATRA. Co-incubation assay confirmed that LP eosinophils induced the differentiation of naive T cells into Treg cells. Differentiation promoted by LP eosinophils were inhibited by blocked either TGF-beta1 or ATRA. Peripheral blood (PB) eosinophils did not produce ATRA and could not induce Treg differentiation. These data identifies LP eosinophils as effective inducers of Treg cell differentiation through a mechanism dependent on TGF-beta1 and ATRA. |
