| First Author | Choi UY | Year | 2014 |
| Journal | PLoS One | Volume | 9 |
| Issue | 4 | Pages | e95805 |
| PubMed ID | 24756037 | Mgi Jnum | J:215171 |
| Mgi Id | MGI:5604820 | Doi | 10.1371/journal.pone.0095805 |
| Citation | Choi UY, et al. (2014) Tripartite motif-containing protein 30 modulates TCR-activated proliferation and effector functions in CD4+ T cells. PLoS One 9(4):e95805 |
| abstractText | To avoid excessive activation, immune signals are tightly controlled by diverse inhibitory proteins. TRIM30, a tripartite motif (TRIM)-containing protein is one of such inhibitors known to function in macrophages. To define the roles of TRIM30, we generated Trim30 knockout (Trim30-/-) mice. Trim30 deletion caused no major developmental defects in any organs, nor showed any discernable defect in the activation of macrophages. But, Trim30-/- mice showed increased CD4/CD8 ratio when aged and Trim30-/- CD4+ T cells exhibited an abnormal response upon TCR activation, in particular in the absence of a costimulatory signal. Adoptive transfer of wild-type and Trim30-/- CD4+ T cells together into lymphopenic hosts confirmed higher proliferation of the Trim30-/- CD4+ T cells in vivo. Despite the enhanced proliferation, Trim30-/- T cells showed decreased levels of NF-kappaB activation and IL-2 production compared to wild-type cells. These results indicate a distinct requirement for TRIM30 in modulation of NF-kappaB activation and cell proliferation induced by TCR stimulation. |
