| First Author | Martin-Blanco N | Year | 2016 |
| Journal | Int Immunol | Volume | 28 |
| Issue | 3 | Pages | 127-37 |
| PubMed ID | 26507128 | Mgi Jnum | J:246188 |
| Mgi Id | MGI:5924289 | Doi | 10.1093/intimm/dxv060 |
| Citation | Martin-Blanco N, et al. (2016) CD3epsilon recruits Numb to promote TCR degradation. Int Immunol 28(3):127-37 |
| abstractText | Modulation of TCR signaling upon ligand binding is achieved by changes in the equilibrium between TCR degradation, recycling and synthesis; surprisingly, the molecular mechanism of such an important process is not fully understood. Here, we describe the role of a new player in the mediation of TCR degradation: the endocytic adaptor Numb. Our data show that Numb inhibition leads to abnormal intracellular distribution and defective TCR degradation in mature T lymphocytes. In addition, we find that Numb simultaneously binds to both Cbl and a site within CD3epsilon that overlaps with the Nck binding site. As a result, Cbl couples specifically to the CD3epsilon chain to mediate TCR degradation. The present study unveils a novel role of Numb that lies at the heart of TCR signaling initiation and termination. |
