| First Author | Hardenberg G | Year | 2008 |
| Journal | J Leukoc Biol | Volume | 84 |
| Issue | 2 | Pages | 380-8 |
| PubMed ID | 18483203 | Mgi Jnum | J:138443 |
| Mgi Id | MGI:3805165 | Doi | 10.1189/jlb.1207853 |
| Citation | Hardenberg G, et al. (2008) APRIL facilitates viral-induced erythroleukemia but is dispensable for T cell immunity and lymphomagenesis. J Leukoc Biol 84(2):380-8 |
| abstractText | The TNF family member, a proliferation-inducing ligand (APRIL), has been suggested to act as a costimulatory molecule in T cell responses. However, studies addressing this role in vivo are largely lacking. Here, we evaluated the effects of APRIL on physiological T cell responses in vivo. Although receptors for APRIL are expressed on a subset of T cells, neither TCR transgenic (Tg) T cell responses nor endogenous TCR responses were affected by Tg APRIL expression in vivo. Moreover, APRIL did not significantly enhance the induction of T cell lymphomas upon Moloney murine leukemia virus (MLV) infection. This clearly contrasts current belief and indicates that APRIL does not serve a major role in T cell immunity or lymphomagenesis. However, we did observe a strong increase in erythroleukemia formation after MLV inoculation of APRIL Tg mice. Strikingly, this erythroleukemia-facilitating property of APRIL was confirmed using the erythroleukemogenic Friend-MLV. Erythroleukemia in APRIL Tg mice was characterized by low hematocrits and grossly enlarged spleens with an increased percentage of erythroid precursors. Altogether, these results unveil new proerythroleukemogenic properties of APRIL. |
