| First Author | Chaves FM | Year | 2020 |
| Journal | Int J Mol Sci | Volume | 21 |
| Issue | 23 | PubMed ID | 33255553 |
| Mgi Jnum | J:304994 | Mgi Id | MGI:6693881 |
| Doi | 10.3390/ijms21238928 | Citation | Chaves FM, et al. (2020) Tumor Necrosis Factor alpha and Interleukin-1beta Acutely Inhibit AgRP Neurons in the Arcuate Nucleus of the Hypothalamus. Int J Mol Sci 21(23):8928 |
| abstractText | Obesity-associated low-grade inflammation favors weight gain, whereas systemic infection frequently leads to anorexia. Thus, inflammatory signals can either induce positive or negative energy balance. In this study, we used whole-cell patch-clamp to investigate the acute effects of three important proinflammatory cytokines, tumor necrosis factor alpha (TNF-alpha), interleukin-6, and interleukin-1beta (IL-1beta) on the membrane excitability of agouti-related peptide (AgRP)- or proopiomelanocortin (POMC)-producing neurons. We found that both TNF-alpha and IL-1beta acutely inhibited the activity of 35-42% of AgRP-producing neurons, whereas very few POMC neurons were depolarized by TNF-alpha. Interleukin-6 induced no acute changes in the activity of AgRP or POMC neurons. Our findings indicate that the effect of TNF-alpha and IL-1beta, especially on the activity of AgRP-producing neurons, may contribute to inflammation-induced anorexia observed during acute inflammatory conditions. |
