| First Author | Itoh T | Year | 1999 |
| Journal | Clin Exp Metastasis | Volume | 17 |
| Issue | 2 | Pages | 177-81 |
| PubMed ID | 10411111 | Mgi Jnum | J:55823 |
| Mgi Id | MGI:1339442 | Doi | 10.1023/a:1006603723759 |
| Citation | Itoh T, et al. (1999) Experimental metastasis is suppressed in MMP-9-deficient mice. Clin Exp Metastasis 17(2):177-81 |
| abstractText | Matrix metalloproteinases (MMPs) are thought to play a key role in tumor invasion and metastasis. The role of MMP-9 (gelatinase B) in tumor metastasis was examined in MMP-9-deficient mice produced by gene targeting using embryonic stem cells. MMP-9-deficient mice develop normally and are fertile. In these mice, the number of metastatic colonies of B16-BL6 melanoma cells or Lewis lung carcinoma cells that were implanted intravenously fell by 45% for B16-BL6 melanoma and 59% for Lewis lung carcinoma (p = 0.03 and p = 0.0043, respectively). Gelatin zymography showed that both tumor cell lines did not secrete MMP-9 by themselves but the host cells surrounding the tumor cells secrete MMP-9 in vivo. These results indicated that host-derived MMP-9 plays an important role in the process of tumor metastasis. |
