| First Author | Nishibe R | Year | 2013 |
| Journal | FEBS Lett | Volume | 587 |
| Issue | 10 | Pages | 1529-35 |
| PubMed ID | 23583447 | Mgi Jnum | J:198470 |
| Mgi Id | MGI:5496773 | Doi | 10.1016/j.febslet.2013.03.034 |
| Citation | Nishibe R, et al. (2013) CIZ1, a p21Cip1/Waf1-interacting protein, functions as a tumor suppressor in vivo. FEBS Lett 587(10):1529-35 |
| abstractText | CIZ1 is a nuclear protein involved in DNA replication and is also implicated in human diseases including cancers. To gain an insight into its function in vivo, we generated mice lacking Ciz1. Ciz1-deficient (Ciz1(-/-)) mice grew without any obvious abnormalities, and Ciz1(-/-) mouse embryonic fibroblasts (MEFs) did not show any defects in cell cycle status, cell growth, and DNA damage response. However, Ciz1(-/-) MEFs were sensitive to hydroxyurea-mediated replication stress and susceptible to oncogene-induced cellular transformation. In addition, Ciz1(-/-) mice developed various types of leukemias by retroviral insertional mutagenesis. These results indicate that CIZ1 functions as a tumor suppressor in vivo. |
