| First Author | Kitaura F | Year | 2019 |
| Journal | PLoS One | Volume | 14 |
| Issue | 7 | Pages | e0220199 |
| PubMed ID | 31329649 | Mgi Jnum | J:277335 |
| Mgi Id | MGI:6330900 | Doi | 10.1371/journal.pone.0220199 |
| Citation | Kitaura F, et al. (2019) Normal B cell development and Pax5 expression in Thy28/ThyN1-deficient mice. PLoS One 14(7):e0220199 |
| abstractText | Thy28, also known as ThyN1, is a highly conserved nuclear protein. We previously showed that in a chicken mature B cell line, Thy28 binds to the promoter of the gene encoding Pax5, a transcription factor essential for B cell development, and positively regulates its expression. Here, we generated a Thy28-deficient mouse line to analyze its potential role in B cell development in mice. Thy28-deficient mice showed normal development of B cells, and the expression of Pax5 was comparable between wild-type and Thy28-deficient primary B cells. Thus, species-specific mechanisms regulate Pax5 expression and B cell development. |
