| First Author | Cobbold SP | Year | 2009 |
| Journal | Proc Natl Acad Sci U S A | Volume | 106 |
| Issue | 29 | Pages | 12055-60 |
| PubMed ID | 19567830 | Mgi Jnum | J:150809 |
| Mgi Id | MGI:3851853 | Doi | 10.1073/pnas.0903919106 |
| Citation | Cobbold SP, et al. (2009) Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc Natl Acad Sci U S A 106(29):12055-60 |
| abstractText | Infectious tolerance describes the process of CD4(+) regulatory T cells (Tregs) converting naive T cells to become additional Tregs. We show that antigen-specific Tregs induce, within skin grafts and dendritic cells, the expression of enzymes that consume at least 5 different essential amino acids (EAAs). T cells fail to proliferate in response to antigen when any 1, or more, of these EAAs are limiting, which is associated with a reduced mammalian target of rapamycin (mTOR) signaling. Inhibition of the mTOR pathway by limiting EAAs, or by specific inhibitors, induces the Treg-specific transcription factor forkhead box P3, which depends on both T cell receptor activation and synergy with TGF-beta. |
