| First Author | Lochner M | Year | 2011 |
| Journal | J Immunol | Volume | 186 |
| Issue | 3 | Pages | 1531-7 |
| PubMed ID | 21178008 | Mgi Jnum | J:168920 |
| Mgi Id | MGI:4939303 | Doi | 10.4049/jimmunol.1001723 |
| Citation | Lochner M, et al. (2011) Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells. J Immunol 186(3):1531-7 |
| abstractText | Retinoic acid-related orphan receptor (ROR)gammat(+) TCRalphabeta(+) cells expressing IL-17, termed Th17 cells, are most abundant in the intestinal lamina propria. Symbiotic microbiota are required for the generation of Th17 cells, but the requirement for microbiota-derived Ag is not documented. In this study, we show that normal numbers of Th17 cells develop in the intestine of mice that express a single TCR in the absence of cognate Ag, whereas the microbiota remains essential for their development. However, such mice, or mice monocolonized with the Th17-inducing segmented filamentous bacteria, fail to induce normal numbers of Foxp3(+) RORgammat(+) T cells, the regulatory counterpart of IL-17(+)RORgammat(+) T cells. These results demonstrate that a complex microbiota and cognate Ag are required to generate a properly regulated set of RORgammat(+) T cells and Th17 cells. |
