| First Author | Bonney EA | Year | 2011 |
| Journal | Immunology | Volume | 134 |
| Issue | 3 | Pages | 270-80 |
| PubMed ID | 21977997 | Mgi Jnum | J:178853 |
| Mgi Id | MGI:5300419 | Doi | 10.1111/j.1365-2567.2011.03486.x |
| Citation | Bonney EA, et al. (2011) Transient modification within a pool of CD4 T cells in the maternal spleen. Immunology 134(3):270-80 |
| abstractText | Classic models suggest maternal tolerance is dependent on regulation of fetal antigen-specific T cell responses. We hypothesize that factors unique to a particular fetal antigen-specific T cell, rather than the state of pregnancy per se, are important determinants of T cell fate during pregnancy. To investigate the fate of fetal antigen-specific CD4 T cells in the systemic circulation, we examined spleen cells in a CD4 T cell receptor transgenic mouse specific for the male antigen H-Y. We observed a transient decrease in CD4(+) Vbeta6(+) cell numbers and, due to transient internalization of CD4, an increase in CD4(-) Vbeta6(+) T cells. Antigen-specific in vitro responsiveness was not depressed by pregnancy. These data suggest that pregnancy supports fluidity in this particular CD4 T cell pool that may, in turn, help to meet competing requirements of maternal immune responsiveness and fetal tolerance. |
