| First Author | Jun JE | Year | 2003 |
| Journal | Immunity | Volume | 18 |
| Issue | 6 | Pages | 751-62 |
| PubMed ID | 12818157 | Mgi Jnum | J:84042 |
| Mgi Id | MGI:2664647 | Doi | 10.1016/s1074-7613(03)00141-9 |
| Citation | Jun JE, et al. (2003) Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity 18(6):751-62 |
| abstractText | In a genome-wide ENU mouse mutagenesis screen a recessive mouse mutation, unmodulated, was isolated with profound defects in humoral immune responses, selective deficits in B cell activation by antigen receptors and T cell costimulation by CD28, and gradual development of atopic dermatitis with hyper-IgE. Mutant B cells are specifically defective in forming connections between antigen receptors and two key signaling pathways for immunogenic responses, NF-kappaB and JNK, but signal normally to calcium, NFAT, and ERK. The mutation alters a conserved leucine in the coiled-coil domain of CARMA-1/CARD11, a member of the MAGUK protein family implicated in organizing multimolecular signaling complexes. These results define Carma-1 as a key regulator of the plasticity in antigen receptor signaling that underpins opposing mechanisms of immunity and tolerance. |
