| First Author | Lee J | Year | 2020 |
| Journal | NPJ Biofilms Microbiomes | Volume | 6 |
| Issue | 1 | Pages | 49 |
| PubMed ID | 33127905 | Mgi Jnum | J:313169 |
| Mgi Id | MGI:6791464 | Doi | 10.1038/s41522-020-00158-4 |
| Citation | Lee J, et al. (2020) Association of a dysbiotic oral microbiota with the development of focal lymphocytic sialadenitis in IkappaB-zeta-deficient mice. NPJ Biofilms Microbiomes 6(1):49 |
| abstractText | Mice lacking IkappaB-zeta, a protein encoded by the Nfkbiz gene, spontaneously develop a Sjogren's syndrome-like disease involving the lachrymal glands, but no salivary gland symptoms have been reported. We found that Nfkbiz(-/-) female mice presented a significantly reduced salivary flow rate, focal lymphocytic sialadenitis (FLS), and a dysbiotic oral microbiota at week 24. To dissect the contributions of genetic and environmental factors to the salivary gland phenotype, Nfkbiz(+/+) and Nfkbiz(-/-) mice were cohoused after weaning and evaluated at week 20. Cohousing alleviated the salivary gland phenotype of Nfkbiz(-/-) mice but did not induce any disease phenotype in Nfkbiz(+/+) mice. Additionally, the oral microbiota in the cohoused mice was synchronized toward that in Nfkbiz(+/+) mice. In conclusion, IkappaB-zeta-deficient mice developed hyposalivation and FLS, in which a dysbiotic oral microbiota played an important role. This finding suggests that the dysbiotic oral microbiota could be a therapeutic target. |
