| First Author | Kat I | Year | 2010 |
| Journal | Int Immunol | Volume | 22 |
| Issue | 2 | Pages | 101-11 |
| PubMed ID | 20038519 | Mgi Jnum | J:157657 |
| Mgi Id | MGI:4431319 | Doi | 10.1093/intimm/dxp120 |
| Citation | Kat I, et al. (2010) B-cell anergy is maintained in anti-DNA transgenic NZB/NZW mice. Int Immunol 22(2):101-11 |
| abstractText | Clonal anergy has been well recognized as an important mechanism of B cell immunologic tolerance. However, the properties of anergic B cells and especially their role in the development of autoimmune disease in susceptible animals have been controversial. Here we show that low-affinity anti-DNA anergic B cells populate the mature B-cell compartment in the mouse spleen in excessive numbers and display paradoxical behavior in response to a combined B-cell receptor/TLR9 activation. Surprisingly, B-cell anergy was maintained in aged NZB/NZW F1 mice that develop a systemic lupus erythematosus (SLE)-like autoimmune disease. In several parameters of anergy, such as calcium mobilization and antibody secretion, the lupus-prone mice appeared more anergic than their non-autoimmune counterparts. We conclude that low-affinity anergic B cells are unlikely to serve as precursors for the high-affinity autoreactive B cells that give rise to pathogenic anti-DNA auto-antibodies in SLE. |
