| First Author | Qi M | Year | 2002 |
| Journal | Cancer Res | Volume | 62 |
| Issue | 2 | Pages | 433-6 |
| PubMed ID | 11809692 | Mgi Jnum | J:74004 |
| Mgi Id | MGI:2157289 | Citation | Qi M, et al. (2002) n-6 Polyunsaturated fatty acids increase skin but not cervical cancer in human papillomavirus 16 transgenic mice. Cancer Res 62(2):433-6 |
| abstractText | Using a mouse with transgenes for the highly oncogenic human papillomavirus type 16, we asked whether a diet high in fat, namely, the n-6 polyunsaturated fatty acid linoleic acid, would influence the development of skin or cervical cancer. Virgin female keratin 14-human papillomavirus 16 transgenic mice were fed control diet or diet with 20% corn oil. The effect of these diets was compared in mice implanted or not implanted with 0.125 mg/60 day release of estradiol. More precancers and cancers of the skin developed faster in mice fed the high-fat diet. Estrogen had no effect on the development of skin cancers. In contrast, estrogen was necessary for the development of cervical cancer, and a high-fat diet had no effect on the development of cervical cancer. |
