| First Author | Bergström Å | Year | 2021 |
| Journal | Transgenic Res | Volume | 30 |
| Issue | 5 | Pages | 701-707 |
| PubMed ID | 34117597 | Mgi Jnum | J:340156 |
| Mgi Id | MGI:7525827 | Doi | 10.1007/s11248-021-00267-6 |
| Citation | Bergstrom A, et al. (2021) Severe liver disease resembling PSC in mice with K5-Cre mediated deletion of Kruppel-like factor 5 (Klf5). Transgenic Res 30(5):701-707 |
| abstractText | Chronic cholestatic liver diseases including primary sclerosing cholangitis (PSC) present a complex spectrum with regards to the cause, age of manifestation and histopathological features. Current treatment options are severely limited primarily due to a paucity of model systems mirroring the disease. Here, we describe the Keratin 5 (K5)-Cre; Klf5(fl/fl) mouse that spontaneously develops severe liver disease during the postnatal period with features resembling PSC including a prominent ductular reaction, fibrotic obliteration of the bile ducts and secondary degeneration/necrosis of liver parenchyma. Over time, there is an expansion of Sox9(+) hepatocytes in the damaged livers suggestive of a hepatocyte-mediated regenerative response. We conclude that Klf5 is required for the normal function of the hepatobiliary system and that the K5-Cre; Klf5(fl/fl) mouse is an excellent model to probe the molecular events interlinking damage and regenerative response in the liver. |
