| Primary Identifier | MGI:3050507 | Allele Type | Chemically induced (other) |
| Attribute String | Null/knockout | Gene | Kif18a |
| Inheritance Mode | Recessive | Transmission | Germline |
| Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> | Is Recombinase | false |
| Is Wild Type | false |
| description | ES cells were mutagenized using ethyl methansulfonate (EMS). Generation 3 mice on a mixed 129S1/SvImJ and C57BL/6 background were identified by examining ductus deferens sperm for defects in morphology, motility, and quantity. |
| molecularNote | The gcd2 mutation affects the highly conserved R308 residue within the KIF18A motor domain. The gcd2 mutation is a G-to-A transition in exon 7. This is a missense mutation that changes an AGA codon to an AAA, leading to the single amino acid change, R308K. Arginine 308 is a highly conserved amino acid in the motor domain of the protein. |
