| First Author | Lebreton A | Year | 2011 |
| Journal | Science | Volume | 331 |
| Issue | 6022 | Pages | 1319-21 |
| PubMed ID | 21252314 | Mgi Jnum | J:169470 |
| Mgi Id | MGI:4941085 | Doi | 10.1126/science.1200120 |
| Citation | Lebreton A, et al. (2011) A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response. Science 331(6022):1319-21 |
| abstractText | Intracellular pathogens such as Listeria monocytogenes subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate interferon (IFN)-stimulated genes (ISGs). IFN-lambda expression was induced in response to infection of epithelial cells with bacteria lacking LntA; however, the BAHD1-chromatin associated complex repressed downstream ISGs. In contrast, in cells infected with lntA-expressing bacteria, LntA prevented BAHD1 recruitment to ISGs and stimulated their expression. Murine listeriosis decreased in BAHD1(+/-) mice or when lntA was constitutively expressed. Thus, the LntA-BAHD1 interplay may modulate IFN-lambda-mediated immune response to control bacterial colonization of the host. |
