| First Author | Mealer RG | Year | 2013 |
| Journal | J Neurosci | Volume | 33 |
| Issue | 9 | Pages | 4206-10 |
| PubMed ID | 23447628 | Mgi Jnum | J:196058 |
| Mgi Id | MGI:5486506 | Doi | 10.1523/JNEUROSCI.3730-12.2013 |
| Citation | Mealer RG, et al. (2013) Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington's disease. J Neurosci 33(9):4206-10 |
| abstractText | Although the mutated protein causing Huntington's disease (HD) is expressed throughout the body, the major pathology of HD is localized to the striatum of the brain. We previously reported that the striatal-enriched protein Rhes binds the mutated huntingtin protein and enhances its cytotoxicity. We now demonstrate that Rhes-deleted mice are dramatically protected from neurotoxicity and motor dysfunction in a striatal-specific model of HD elicited by 3-nitropropionic acid. This finding suggests that Rhes may, in part, determine the striatal selectivity of HD. |
