| First Author | Klug DB | Year | 2000 |
| Journal | J Immunol | Volume | 164 |
| Issue | 4 | Pages | 1881-8 |
| PubMed ID | 10657637 | Mgi Jnum | J:60329 |
| Mgi Id | MGI:1353175 | Doi | 10.4049/jimmunol.164.4.1881 |
| Citation | Klug DB, et al. (2000) Transgenic expression of cyclin D1 in thymic epithelial precursors promotes epithelial and T cell development. J Immunol 164(4):1881-8 |
| abstractText | We previously reported that precursors within the keratin (K) 8+5+ thymic epithelial cell (TEC) subset generate the major cortical K8+5- TEC population in a process dependent on T lineage commitment. This report demonstrates that expression of a cyclin D1 transgene in K8+5+ TECs expands this subset and promotes TEC and thymocyte development. Cyclin D1 transgene expression is not sufficient to induce TEC differentiation in the absence of T lineage-committed thymocytes because TECs from both hCD3epsilon transgenic and hCD3epsilon/cyclin D1 double transgenic mice remain blocked at the K8+5+ maturation stage. However, enforced cyclin D1 expression does expand the developmental window during which K8+5+ cells can differentiate in response to normal hemopoietic precursors. Thus, enhancement of thymic function may be achieved by manipulating the growth and/or survival of TEC precursors within the K8+5+ subset. |
