| First Author | Holländer GA | Year | 1995 |
| Journal | Immunity | Volume | 3 |
| Issue | 1 | Pages | 27-38 |
| PubMed ID | 7621076 | Mgi Jnum | J:27235 |
| Mgi Id | MGI:74652 | Doi | 10.1016/1074-7613(95)90156-6 |
| Citation | Hollander GA, et al. (1995) Severe colitis in mice with aberrant thymic selection. Immunity 3(1):27-38 |
| abstractText | Tg epsilon 26 mice display an arrest very early in T cell development that has a profound effect on the architecture of thymic stromal cells. We have recently demonstrated that transplantation of wild-type bone marrow cells restores the thymic microenvironment of fetal but not adult Tg epsilon 26 mice. Here, we report that T cell-reconstituted adult Tg epsilon 26 mice develop a spontaneous wasting syndrome characterized by extensive inflammation of the colon, resembling human ulcerative colitis. Colitis in these animals was marked by substantial infiltration of the colon by activated thymus-derived CD4+ T cells. Importantly, bone marrow-transplanted Tg epsilon 26 mice previously engrafted with a fetal Tg epsilon 26 thymus did not develop colitis. These results suggest that T cells selected in an aberrant thymic microenvironment contain a population of cells able to induce severe colitis that can be prevented by T cells that have undergone normal thymic development. |
