| First Author | Enriquez JR | Year | 2022 |
| Journal | Cell Rep | Volume | 41 |
| Issue | 7 | Pages | 111641 |
| PubMed ID | 36384107 | Mgi Jnum | J:331375 |
| Mgi Id | MGI:7388027 | Doi | 10.1016/j.celrep.2022.111641 |
| Citation | Enriquez JR, et al. (2022) A dietary change to a high-fat diet initiates a rapid adaptation of the intestine. Cell Rep 41(7):111641 |
| abstractText | Long-term impacts of diet have been well studied; however, the immediate response of the intestinal epithelium to a change in nutrients remains poorly understood. We use physiological metrics and single-cell transcriptomics to interrogate the intestinal epithelial cell response to a high-fat diet (HFD). Within 1 day of HFD exposure, mice exhibit altered whole-body physiology and increased intestinal epithelial proliferation. Single-cell transcriptional analysis on day 1 reveals a cell-stress response in intestinal crypts and a shift toward fatty acid metabolism. By 3 days of HFD, computational trajectory analysis suggests an emergence of progenitors, with a transcriptional profile shifting from secretory populations toward enterocytes. Furthermore, enterocytes upregulate lipid absorption genes and show increased lipid absorption in vivo over 7 days of HFD. These findings demonstrate the rapid intestinal epithelial response to a dietary change and help illustrate the essential ability of animals to adapt to shifting nutritional environments. |
