| First Author | Nakajima M | Year | 2004 |
| Journal | Dev Dyn | Volume | 230 |
| Issue | 4 | Pages | 795-9 |
| PubMed ID | 15254914 | Mgi Jnum | J:91716 |
| Mgi Id | MGI:3050263 | Doi | 10.1002/dvdy.20098 |
| Citation | Nakajima M, et al. (2004) Presenilin 1 is essential for cardiac morphogenesis. Dev Dyn 230(4):795-9 |
| abstractText | Presenilin 1 (PS1) is the gene responsible for the development of early-onset familial Alzheimer's disease. PS1-deficient mice have been reported to show defects in neurogenesis, somitogenesis and angiogenesis. Here, we report cardiac anomaly in PS1-deficient mice: the mutant hearts exhibited ventricular septal defect, double outlet right ventricle, and stenosis in the pulmonary artery. Immunohistochemistry using anti-PS1 antibody revealed the prominent expression of PS1 in mesenchymal cells at the septal area of the wild-type heart. These results suggest that PS1 may play an essential role in heart development. |
