| First Author | Ohnishi YN | Year | 2015 |
| Journal | Neuroscience | Volume | 284 |
| Pages | 165-70 | PubMed ID | 25313003 |
| Mgi Jnum | J:221455 | Mgi Id | MGI:5639187 |
| Doi | 10.1016/j.neuroscience.2014.10.002 | Citation | Ohnishi YN, et al. (2015) Functional role of the N-terminal domain of DeltaFosB in response to stress and drugs of abuse. Neuroscience 284:165-70 |
| abstractText | Previous work has implicated the transcription factor, DeltaFosB, acting in the nucleus accumbens, in mediating the pro-rewarding effects of drugs of abuse such as cocaine as well as in mediating resilience to chronic social stress. However, the transgenic and viral gene transfer models used to establish these DeltaFosB phenotypes express, in addition to DeltaFosB, an alternative translation product of DeltaFosB mRNA, termed Delta2DeltaFosB, which lacks the N-terminal 78 aa present in DeltaFosB. To study the possible contribution of Delta2DeltaFosB to these drug and stress phenotypes, we prepared a viral vector that overexpresses a point mutant form of DeltaFosB mRNA which cannot undergo alternative translation as well as a vector that overexpresses Delta2DeltaFosB alone. Our results show that the mutant form of DeltaFosB, when overexpressed in the nucleus accumbens, reproduces the enhancement of reward and of resilience seen with our earlier models, with no effects seen for Delta2DeltaFosB. Overexpression of full length FosB, the other major product of the FosB gene, also has no effect. These findings confirm the unique role of DeltaFosB in the nucleus accumbens in controlling responses to drugs of abuse and stress. |
