| First Author | Adler H | Year | 2009 |
| Journal | PLoS One | Volume | 4 |
| Issue | 7 | Pages | e6317 |
| PubMed ID | 19621080 | Mgi Jnum | J:151540 |
| Mgi Id | MGI:4354421 | Doi | 10.1371/journal.pone.0006317 |
| Citation | Adler H, et al. (2009) Perturbation of lytic and latent gammaherpesvirus infection in the absence of the inhibitory receptor CEACAM1. PLoS One 4(7):e6317 |
| abstractText | Control of gammaherpesvirus infections requires a complex, well orchestrated immune response regulated by positive and negative co-signaling molecules. While the impact of co-stimulatory molecules has been addressed in various studies, the role of co-inhibitory receptors has not been tested. The ITIM-bearing CEACAM1 is an inhibitory receptor expressed by a variety of immune cells, including B, T and NK cells. Using Ceacam1(-/-) mice, we analyzed the in vivo function of CEACAM1 during acute and latent murine gammaherpesvirus 68 (MHV-68) infection. During acute lytic replication, we observed lower virus titers in the lungs of Ceacam1(-/-) mice than in WT mice. In contrast, during latency amplification, Ceacam1(-/-) mice displayed increased splenomegaly and a higher latent viral load in the spleen. Analysis of the immune response revealed increased virus-specific antibody levels in Ceacam1(-/-) mice, while the magnitude of the T cell-mediated antiviral immune response was reduced. These findings suggest that inhibitory receptors can modulate the efficacy of immune responses against gammaherpesvirus infections. |
