| First Author | Lucassen EA | Year | 2012 |
| Journal | Eur J Neurosci | Volume | 35 |
| Issue | 9 | Pages | 1466-74 |
| PubMed ID | 22512278 | Mgi Jnum | J:191449 |
| Mgi Id | MGI:5461773 | Doi | 10.1111/j.1460-9568.2012.08054.x |
| Citation | Lucassen EA, et al. (2012) Role of vasoactive intestinal peptide in seasonal encoding by the suprachiasmatic nucleus clock. Eur J Neurosci 35(9):1466-74 |
| abstractText | The neuropeptide vasoactive intestinal peptide (VIP) is critical for the proper functioning of the neural circuit that generates circadian rhythms. Mice lacking VIP show profound deficits in the ability to generate many behavioral and physiological rhythms. To explore how the loss of VIP impacts on the intact circadian system, we carried out in vivo multiunit neural activity (MUA) recordings from the suprachiasmatic nucleus of freely moving VIP knockout (KO) mice. The MUA rhythms were largely unaltered in the VIP KO mice, with no significant differences being seen in the amplitude or phase of the rhythms in light-dark conditions. Robust differences between the genotypes were revealed when the mice were transferred from light-dark to constant darkness conditions. In addition, the ability of the VIP KO mice to encode changes in photoperiod was examined. Strikingly, the behavioral and physiological rhythms of VIP KO mice showed no adaptation to short or long photoperiods. The data indicate that the intact circadian system can compensate for some of the consequences of the loss of VIP, whereas this peptide is indispensable for endogenous encoding of seasonal information. |
