| First Author | Gavini CK | Year | 2018 |
| Journal | Cell Rep | Volume | 25 |
| Issue | 2 | Pages | 271-277.e4 |
| PubMed ID | 30304667 | Mgi Jnum | J:271114 |
| Mgi Id | MGI:6278437 | Doi | 10.1016/j.celrep.2018.09.046 |
| Citation | Gavini CK, et al. (2018) Liver X Receptors Protect Dorsal Root Ganglia from Obesity-Induced Endoplasmic Reticulum Stress and Mechanical Allodynia. Cell Rep 25(2):271-277.e4 |
| abstractText | Obesity is associated with many complications, including type 2 diabetes and painful neuropathy. There is no cure or prevention for obesity-induced pain, and the neurobiology underlying the onset of the disease is still obscure. In this study, we observe that western diet (WD)-fed mice developed early allodynia with an increase of ER stress markers in the sensory neurons of the dorsal root ganglia (DRG). Using cell-specific approaches, we demonstrate that neuronal liver X receptor (LXR) activation delays ER stress and allodynia in WD-fed mice. Our findings suggest that lipid-binding nuclear receptors expressed in the sensory neurons of the DRG play a role in the onset of obesity-induced hypersensitivity. The LXR and lipid-sensor pathways represent a research avenue to identify targets to prevent debilitating complications affecting the peripheral nerve system in obesity. |
