| Primary Identifier | MGI:3053165 | Allele Type | Transgenic |
| Attribute String | Reporter | Gene | Tg(Nes-Hspa1b-EGFP)50Okn |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| description | Of six transgenic lines generated, only that designated #25 is described in the reference; it was noted that all lines had similar expression patterns. |
| molecularNote | Enhanced green fluorescent protein is expressed from the Hspa1b promoter under control of the second-intronic transcription enhancer of the rat nestin gene. Cells from embryonic brain that expressed high levels of EGFP included a subpopulation having characteristics of neural stem cells (NSCs) - capability for proliferation, self-renewal, and generation of both neural and glial cells - whereas few putative NSCs were observed among low- or non-expressing cells. In adult mice, EGFP expressing cells, which occur only in the periventricular region, include a population of slowly dividing, multipotential progenitor cells that likely represent adult stem cells. |
