| First Author | Li B | Year | 2014 |
| Journal | Nat Neurosci | Volume | 17 |
| Issue | 8 | Pages | 1055-63 |
| PubMed ID | 24952642 | Mgi Jnum | J:214975 |
| Mgi Id | MGI:5604313 | Doi | 10.1038/nn.3744 |
| Citation | Li B, et al. (2014) Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling. Nat Neurosci 17(8):1055-63 |
| abstractText | Ion channels are essential for the regulation of neuronal functions. The significance of plasma membrane, mitochondrial, endoplasmic reticulum and lysosomal ion channels in the regulation of Ca(2+) is well established. In contrast, surprisingly little is known about the function of ion channels on the nuclear envelope (NE). Here we demonstrate the presence of functional large-conductance, calcium-activated potassium channels (BK channels) on the NE of rodent hippocampal neurons. Functionally, blockade of nuclear BK channels (nBK channels) induces NE-derived Ca(2+) release, nucleoplasmic Ca(2+) elevation and cyclic AMP response element binding protein (CREB)-dependent transcription. More importantly, blockade of nBK channels regulates nuclear Ca(2+)-sensitive gene expression and promotes dendritic arborization in a nuclear Ca(2+)-dependent manner. These results suggest that the nBK channel functions as a molecular link between neuronal activity and nuclear Ca(2+) to convey signals from synapse to nucleus and is a new modulator, operating at the NE, of synaptic activity-dependent neuronal functions. |
