| First Author | Foskolou IP | Year | 2023 |
| Journal | Cell Rep | Volume | 42 |
| Issue | 9 | Pages | 113013 |
| PubMed ID | 37632752 | Mgi Jnum | J:351830 |
| Mgi Id | MGI:7525048 | Doi | 10.1016/j.celrep.2023.113013 |
| Citation | Foskolou IP, et al. (2023) The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function. Cell Rep 42(9):113013 |
| abstractText | 2-Hydroxyglutarate (2HG) is a byproduct of the tricarboxylic acid (TCA) cycle and is readily detected in the tissues of healthy individuals. 2HG is found in two enantiomeric forms: S-2HG and R-2HG. Here, we investigate the differential roles of these two enantiomers in cluster of differentiation (CD)8(+) T cell biology, where we find they have highly divergent effects on proliferation, differentiation, and T cell function. We show here an analysis of structural determinants that likely underlie these differential effects on specific alpha-ketoglutarate (alphaKG)-dependent enzymes. Treatment of CD8(+) T cells with exogenous S-2HG, but not R-2HG, increased CD8(+) T cell fitness in vivo and enhanced anti-tumor activity. These data show that S-2HG and R-2HG should be considered as two distinct and important actors in the regulation of T cell function. |
