| First Author | Bustos-Morán E | Year | 2019 |
| Journal | Sci Rep | Volume | 9 |
| Issue | 1 | Pages | 2211 |
| PubMed ID | 30778113 | Mgi Jnum | J:275440 |
| Mgi Id | MGI:6304843 | Doi | 10.1038/s41598-019-38647-y |
| Citation | Bustos-Moran E, et al. (2019) Aurora A controls CD8(+) T cell cytotoxic activity and antiviral response. Sci Rep 9(1):2211 |
| abstractText | Aurora A is a serine/threonine kinase whose role in cell cycle progression and tumour generation has been widely studied. Recent work has revealed an unexpected function for Aurora A during CD4(+) T cell activation and, also, in graft versus host disease development. However, it remains unknown whether Aurora A is involved in CD8(+) T cell effector function and in cytotoxic T lymphocyte-mediated antiviral response. Here, we show that Aurora A chemical inhibition leads to an impairment of both the peptide-specific cytotoxicity and the degranulation activity of CD8(+) T cells. This finding was similarly proven for both mice and human CD8(+) CTL activity. As a result of Aurora A blockade, we detected a reduction in the expression induced by T cell activation of genes classically related to the effector function of cytotoxic T lymphocytes such as granzyme B or perforin1. Finally, we have found that Aurora A is necessary for CD8(+) T cell-mediated antiviral response, in an in vivo model of vaccinia virus infection. Thus, we can conclude that Aurora A activity is, indeed, needed for the proper effector function of cytotoxic T lymphocytes and for their activity against viral threats. |
