| First Author | Salmond RJ | Year | 2014 |
| Journal | Nat Immunol | Volume | 15 |
| Issue | 9 | Pages | 875-883 |
| PubMed ID | 25108421 | Mgi Jnum | J:259368 |
| Mgi Id | MGI:6142292 | Doi | 10.1038/ni.2958 |
| Citation | Salmond RJ, et al. (2014) The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals. Nat Immunol 15(9):875-883 |
| abstractText | T cells must be tolerant of self antigens to avoid autoimmunity but responsive to foreign antigens to provide protection against infection. We found that in both naive T cells and effector T cells, the tyrosine phosphatase PTPN22 limited signaling via the T cell antigen receptor (TCR) by weak agonists and self antigens while not impeding responses to strong agonist antigens. T cells lacking PTPN22 showed enhanced formation of conjugates with antigen-presenting cells pulsed with weak peptides, which led to activation of the T cells and their production of inflammatory cytokines. This effect was exacerbated under conditions of lymphopenia, with the formation of potent memory T cells in the absence of PTPN22. Our data address how loss-of-function PTPN22 alleles can lead to the population expansion of effector and/or memory T cells and a predisposition to human autoimmunity. |
