| First Author | Goldberger O | Year | 2008 |
| Journal | Cancer Res | Volume | 68 |
| Issue | 9 | Pages | 3450-7 |
| PubMed ID | 18451173 | Mgi Jnum | J:134776 |
| Mgi Id | MGI:3789787 | Doi | 10.1158/0008-5472.CAN-07-5006 |
| Citation | Goldberger O, et al. (2008) Exuberated numbers of tumor-specific T cells result in tumor escape. Cancer Res 68(9):3450-7 |
| abstractText | Cytotoxic T cells (CTL) play a major role in tumor rejection. Expansion of CTLs, either by immunization or adoptive transfer, is a prominent goal in current immunotherapy. The antigen-specific nature of these expansion processes inevitably initiates a clonotypic attack on the tumor. By injecting an Ovalbumin-expressing melanoma into OT-I mice, in which >90% of CTLs recognize an Ovalbumin peptide, we show that an increased number of tumor-specific CTLs causes emergence of escape variants. We show that these escape variants are a result of antigen silencing via a yet undetermined epigenetic mechanism, which occurs frequently and is spontaneously reversible. We further show that an increase in the time of tumor onset in OT-I compared with C57BL/6J is a result of immune selection. |
