| First Author | Duan Q | Year | 2021 |
| Journal | Front Cell Dev Biol | Volume | 9 |
| Pages | 761193 | PubMed ID | 34966740 |
| Mgi Jnum | J:316920 | Mgi Id | MGI:6842680 |
| Doi | 10.3389/fcell.2021.761193 | Citation | Duan Q, et al. (2021) Sirtuin 5 is Dispensable for CD8(+) T Cell Effector and Memory Differentiation. Front Cell Dev Biol 9:761193 |
| abstractText | CD8(+) T cell effector and memory differentiation is tightly controlled at multiple levels including transcriptional, metabolic, and epigenetic regulation. Sirtuin 5 (SIRT5) is a protein deacetylase mainly located at mitochondria, but it remains unclear whether SIRT5 plays key roles in regulating CD8(+) T cell effector or memory formation. Herein, with adoptive transfer of Sirt5(+/+) or Sirt5(-/-) OT-1 cells and acute Listeria monocytogenes infection model, we demonstrate that SIRT5 deficiency does not affect CD8(+) T cell effector function and that SIRT5 is not required for CD8(+) T cell memory formation. Moreover, the recall response of SIRT5 deficient memory CD8(+) T cells is comparable with Sirt5(+/+) memory CD8(+) T cells. Together, these observations suggest that SIRT5 is dispensable for the effector function and memory differentiation of CD8(+) T cells. |
