| First Author | Teixeiro E | Year | 2009 |
| Journal | Science | Volume | 323 |
| Issue | 5913 | Pages | 502-5 |
| PubMed ID | 19164748 | Mgi Jnum | J:144175 |
| Mgi Id | MGI:3830395 | Doi | 10.1126/science.1163612 |
| Citation | Teixeiro E, et al. (2009) Different T cell receptor signals determine CD8+ memory versus effector development. Science 323(5913):502-5 |
| abstractText | Following infection, naive CD8+ T cells bearing pathogen-specific T cell receptors (TCRs) differentiate into a mixed population of short-lived effector and long-lived memory T cells to mediate an adaptive immune response. How the TCR regulates memory T cell development has remained elusive. Using a mutant TCR transgenic model, we found that point mutations in the TCR beta transmembrane domain (betaTMD) impair the development and function of CD8+ memory T cells without affecting primary effector T cell responses. Mutant T cells are deficient in polarizing the TCR and in organizing the nuclear factor kappaB signal at the immunological synapse. Thus, effector and memory states of CD8+ T cells are separable fates, determined by differential TCR signaling. |
