| Primary Identifier | MGI:3053982 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Mt1-RET)242Ina |
| Strain of Origin | (BALB/c x C57BL/6) X BALB/c | Is Recombinase | false |
| Is Wild Type | false |
| description | Sublines 242A, 242B and 242C were derived by crossing early descendants of female founder 242, on a mixed BALB/c and C57BL/6 background, to C57BL/6, (BALB/c x C57BL/6)F1 or BALB/c mice, respectively, then intercrossing the progeny. Other founder lines were 108, 192, 207, 301, 304 and 319. |
| molecularNote | The transgene comprises the cDNA encoding the human ret proto-oncogene driven by the mouse metallothionein 1 promoter/enhancer and followed by a segment of the simian virus 40 (SV40) genome containing a splice signal, a polyadenylation signal and 3' flanking sequence. Northern blot analysis revealed low levels of transgene expression in hyperpigmented skin of non-albino mice of this line. |
